The science

The neuroscience of concussion recovery.

What actually happens in the brain after a concussion — and how each ingredient was chosen to support it. Explained honestly, evidence first.

The neurometabolic cascade

A concussion triggers an energy crisis in the brain.

The injury isn't only mechanical. It sets off a cascade where cells demand more energy exactly when they can make less — the window where recovery needs the most support.

1
Impact

Mechanical force stretches and disrupts neurons.

2
Ionic flux

Cells fire uncontrollably; ion pumps work overtime.

3
Energy crisis

ATP demand spikes while mitochondria are impaired.

4
Vulnerability window

Days to weeks when the brain needs support most.

5
Recovery

Energy, antioxidant, inflammatory, and signaling systems rebalance.

Framework based on the widely cited neurometabolic cascade literature (e.g., Giza & Hovda). Educational; not a diagnosis.

The five pathways

Five places recovery can stall — and how the formula supports each.

Each pathway pairs a mechanism with the actives chosen to support it. "Supports" — not treats or cures.

01 / Energy & Mitochondria

Fueling the demand.

After injury the brain's energy demand spikes. This pathway supports cellular ATP production so neurons can meet that demand during recovery.

Key actives: Creatine Monohydrate (5g), Magnesium Taurinate
02 / Oxidative Balance

Calming the stress.

Injury drives oxidative and metabolic stress. Antioxidant support helps neutralize unstable molecules and protect the cell membrane.

Key actives: NAC (600mg), Broccoli Powder, Resveratrol
03 / Neuroinflammation

Keeping it balanced.

A balanced inflammatory response is protective; a prolonged one isn't. This pathway supports a healthy, resolving neuroinflammatory response.

Key actives: Turmeric (95% curcumin, 1g), Resveratrol, Black Pepper
04 / Neurotransmitters

Steady signaling.

Recovery depends on balanced signaling. This pathway supports healthy neurotransmitter systems involved in mood, focus, and cognition.

Key actives: Magnesium Taurinate (153mg), Creatine
05 / Synaptic Health

Rebuilding connections.

Neurons rebuild and reconnect. This pathway supports neural signaling, communication, and overall pathway integrity.

Key actives: Magnesium Taurinate, Creatine
The research, honestly stated

Every ingredient, with what the evidence does and doesn't show.

We'd rather be candid than overclaim. Here's the reasoning behind each active — the honesty is the point.

Creatine Monohydrate 5 g
Supports the brain's phosphocreatine energy system — directly relevant to the post-injury energy gap. One of the most-studied supplements for cellular energy.
Turmeric Root Extract (95% curcumin) 1 g
Curcumin is studied for supporting a healthy inflammatory response and antioxidant activity. Standardized to 95% curcuminoids; paired with black pepper for absorption.
N-Acetyl Cysteine (NAC) 600 mg
A precursor to glutathione, the body's key antioxidant — relevant to the oxidative-stress pathway after injury.
Broccoli Powder (sulforaphane source) 500 mg
A natural source of compounds studied for activating the body's own antioxidant (Nrf2) defenses.
Polygonum Cuspidatum (98% resveratrol) 250 mg
Resveratrol is studied for antioxidant and cellular-signaling support.
Magnesium (from Magnesium Taurinate) 153 mg
Magnesium supports synaptic signaling and neuronal function; the taurinate form pairs it with taurine.
Naringin + Black Pepper Extract 200 mg · 10 mg
Bioflavonoid and piperine that support absorption and antioxidant activity of the other actives. Every dose is disclosed — no proprietary blends.

Ingredient claims use "supports" framing and reflect general nutritional science, not concussion treatment claims. Always consult your healthcare provider.

Who formulated it

A clinical pharmacist who needed it himself.

ConcussionCare+ was born from Dr. Jon MacKay's own concussion — and the frustration of recovering on outdated advice. Two years and 200+ studies later, he built the formula and the free recovery app he wished he'd had.

Dr. Jon MacKay, PharmD, BCACP · 200+ studies reviewed · 8 research-backed ingredients

Ready to support your recovery?

A transparent, multi-pathway formula — plus the free recovery app.

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